|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Red top tube 5 mL (Clot Activator)|
Normal: > 4.1 ng/mL Indeterminate: 2.2 - 4.1 ng/mL Deficient: < 2.2 ng/mL All enriched grains have been fortified with folic acid in the U.S. since 1998 and therefore the prevalence of folate deficiency is low (1%). Testing for folate deficiency is strongly discouraged unless profound malnutrition is suspected and other causes of anemia have been excluded.
The assay is unaffected by icterus (bilirubin is less than 29 mg/dL), lipemia (triglycerides is less than 1500 mg/dL), hemolysis (Hb less than 40 mg/dL) and biotin is less than 40 ng/mL. Criterion: recovery within plus or minus 0.5 ng/mL (1.1 nmol/l) at folate levels is less than 5 ng/mL (11 nmol/l), or within plus or minus 10% at folate levels is greater than 5 ng/mL (11 nmol/l). No interference was observed from rheumatoid factors up to a concentration of 1000 U/mL. In vitro tests were performed on 56 commonly used pharmaceuticals. No interference with the assay was found. Folate assays of samples from patients receiving therapy with certain pharmaceuticals, e.g. methotrexate or leucovorin, are contraindicated because of the cross-reactivity of folate binding protein with these compounds. In rare cases interference due to extremely high titers of antibodies to streptavidin and ruthenium can occur. For diagnostic purposes, the Folate findings should always be assessed in conjunction with the patient's medical history, clinical examination and other findings.
RBC Folate, Whole Blood