Chromatin Antibody
Label Mnemonic: CHROM
Epic Lab Code: LAB7827
Downtime Form: A-1a General Laboratory Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3.0 mL whole blood from light green top tube or TWO Microtainer® devices
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
3 hours (upon receipt in laboratory)
Reference Range:
1.0 AI (antibody index) or less
Interpretive Data:
Antibodies to chromatin (DNA complexed with histone proteins) are found in >50% of patients with systemic lupus erythematosus (SLE), and are significantly associated with kidney disease in this patient group. Chromatin antibodies may be found in patients with drug-induced lupus. Chromatin antibodies may also be found in patients with autoimmune hepatitis, and Sjogren's syndrome.
Comments:
New assay introduced February 25, 2013.
Methodology:
Multiplex flow immunoassay
CPT Code:
86235