Chromatin Antibody

Label Mnemonic:	CHROM
Epic code:	LAB7827
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Plasma

Collection Medium:

Plasma Separator Tube 4.5 mL

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3.0 mL whole blood from light green top tube or TWO Microtainer^® devices

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

3 hours (upon receipt in laboratory)

Reference Range:

1.0 AI (antibody index) or less

Interpretive Data:

Antibodies to chromatin (DNA complexed with histone proteins) are found in >50% of patients with systemic lupus erythematosus (SLE), and are significantly associated with kidney disease in this patient group. Chromatin antibodies may be found in patients with drug-induced lupus. Chromatin antibodies may also be found in patients with autoimmune hepatitis, and Sjogren's syndrome.

Comments:

New assay introduced February 25, 2013.

Methodology:

Multiplex flow immunoassay

CPT Code:

86235

See also:
Anti-Nuclear Antibody Screen and Reflex Titer by IFA, Serum
Double Stranded DNA Antibody, Plasma
RNP Antibody, Plasma
Ribosomal P Protein, Plasma
SS-A Antibody, Plasma
SS-B Antibody, Plasma
Sm/RNP (Common Motif) Antibodies, Plasma