Cryoglobulin, Qual with Reflex to IFE Typing & Immunoglobulins
Label Mnemonic: | CRYTYP |
Epic code: | LAB7635 |
Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum (in two pre-warmed tubes)
Specimen
Instructions:
It is critical to keep specimen warm
(37°C) during transport. Keep specimen at body temperature
(e.g.,
under arm) and deliver immediately to Specimen Control. Spin within
one hour of collection time.
Fasting specimen required.
Fasting specimen required.
Collection Medium:
and | ||
Red top tube 5 mL (Clot Activator) | Red top tube 5 mL (Clot Activator) |
Minimum:
3 mL serum in red top tube
Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.
Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.
Rejection Criteria:
Plasma. Serum separator tubes. Grossly hemolyzed or lipemic
specimens.
Turn Around
Time:
3-5 days upon receipt at reference laboratory.
Reference Range:
Cryoglobulin, Qualitative - Negative at 72 hours.
Immunofixation Electrophoresis Gel - Normal IFE
Immunoglobulin A, Cryoprecipitate - 0 mg/dL
Immunoglobulin G, Cryoprecipitate - 0 mg/dL
Immunoglobulin M, Cryoprecipitate - 0 mg/dL
Immunofixation Electrophoresis Gel - Normal IFE
Immunoglobulin A, Cryoprecipitate - 0 mg/dL
Immunoglobulin G, Cryoprecipitate - 0 mg/dL
Immunoglobulin M, Cryoprecipitate - 0 mg/dL
Interpretive Data:
Note: Cryoglobulins are usually associated with certain plasma cell
and lymphoproliferative disorders, but have also been demonstrated in
collagen vascular disease, hepatitis C infection, and infections such
as infectious mononucleosis and cytomegalovirus disease.
If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.
If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.
Comments:
If no IFE is desired order test CRYO (LAB1294). Incubate unspun red
top tubes at 37°C for 45 minutes, if clotted remove. If not
clotted incubate for an additional 15 minutes at 37°C. Total
incubation time is 1 hour (do not exceed). Spin at room temperature
and aliquot 1.5 mL each into 2 aliquot tubes. Store and send room
temperature. If only 1 red top received continue with process and
note "1 tube received".
Methodology:
Qualitative Cold Precipitation/Qualitative Immunofixation
Electrophoresis/Quantitative Nephelometry
CPT Code:
82595 Cryoglobulin; if reflexed for positive cryoglobulins, add 86334
for IFE typing and 82784 x3 for the quantitative IgA, IgG, and IgM
concentrations on the cryoprecipitate.
See Additional Information:
Fasting Specimen Requirements
Fasting Specimen Requirements