(in two pre-warmed tubes)

It is critical to keep specimen warm (37°C) during transport. Keep specimen at body temperature (e.g., under arm) and deliver immediately to Specimen Control. Spin within one hour of collection time.

IRL collections from 0715 to 1900 only.

Fasting specimen required.

Preferred Minimum: 3 mL serum
Absolute Minimum: 1 mL serum

Proper collection and transport of specimen is critical to the outcome of the assay. Quantities less than 3 mL may affect the sensitivity of the assay.

Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.

3-5 days upon receipt at reference laboratory.

Cryoglobulin, Qualitative - Negative at 72 hours.
Immunoglobulin A, Cryoprecipitate - None detected
Immunoglobulin G, Cryoprecipitate - None detected
Immunoglobulin M, Cryoprecipitate - None detected

The sample is examined daily for the presence or absence of cryoglobulin.

Note: Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.

If IFE reflex is desired order test CRYTYP (LAB7635). Incubate unspun red top tubes at 37°C for 45 minutes, if clotted remove. If not clotted incubate for an additional 15 minutes at 37°C. Total incubation time is 1 hour (do not exceed). Spin at room temperature and aliquot 1.5 mL each into 2 aliquot tubes. Store and send room temperature. If only 1 red top received, continue with process and note "1 tube received".

Qualitative Cold Precipitation/Quantitative Nephelometry