Coccidioides Antibodies CSF by CF, ID, ELISA, CSF

Order Code:	COCCICSF
Epic Lab Code:	LAB2893
Order Form:	A-1a Miscellaneous Request or Epic Req

Commercial Mail-out Laboratory
6240 RCP
356-3527

Specimen:

CSF

Collection Medium:

CSF container

Minimum:

Preferred minimum: TWO 1 mL aliquot CSF Absolute minimum: TWO 0.5 mL aliquot CSF

Rejection Criteria:

Grossly bloody or hemolyzed specimens.

Analytic Time:

1 week upon receipt at reference laboratory

Reference Range:

Component Name Reference Range Coccidioides Antibody by CF: < 1:2 Coccidioides Antibody by ID: None detected Coccidioides Antibody, IgG by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgG antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful 1.5 IV or greater = Positive Positive-Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection. Coccidioides Antibody, IgM by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgM antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.5 IV or greater = Positive Positive-Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Test Limitations:

Note: Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10% of patients with coccidioidal meningitis will not have antibody in CSF. Negative fungal serology does not rule out the possibility of current infection.

Methodology:

Complement Fixation (CF) Immunodiffusion (ID) Enzyme-Linked Immunosorbent Assay (EIA)

CPT Code:

86635 Cocci Ab (CF) 86635 Cocci Ab (ID) 86635 Cocci IgG (EIA) 86635 Cocci IgM (EIA)