Adult preferred minimum: TWO 1 mL aliquots of serum Adult absolute minimum: 0.5 mL serum Pediatric Minimum: 0.3 mL serum

Component Name Reference Range Coccidioides Antibody by CF: < 1:2 Coccidioides Antibody by ID: None detected Coccidioides Antibody, IgG by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgG antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful 1.5 IV or greater = Positive Positive-Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection. Coccidioides Antibody, IgM by ELISA: 0.9 IV or less = Negative Negative-No significant level of Coccidioides IgM antibody detected. 1.0-1.4 IV = Equivocal Equivocal-Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. 1.5 IV or greater = Positive Positive-Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.

Note: For Coccidioides, immunodiffusion (ID) measures IgM antibodies, while complement fixation (CF) measures both IgG and IgM. ELISA tests can be used to detect both coccidioidal IgG and IgM antibodies. While elevated single antibody titers may be diagnostic, paired samples are preferred. Acute and convalescent samples (drawn at least 21 days apart), showing a fourfold or greater rise in titer, are diagnostic. Negative fungal serology does not rule out the possibility of current infection.

Complement Fixation (CF) Immunodiffusion (ID) Enzyme-Linked Immunosorbent Assay (EIA)

86635 Cocci Ab (CF) 86635 Cocci Ab (ID) 86635 Cocci Ab, IgG (EIA) 86635 Cocci Ab, IgM (EIA)