Centromere B Antibody
| Label Mnemonic: | CENTB |
| Epic code: | LAB7828 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 86235 |
Specimen(s):
Plasma
Collection Medium:
|
| Plasma Separator Tube 4.5 mL |
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection
containers.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
3 hours (upon receipt in laboratory)
Reference Range:
1.0 AI (antibody index) or less
Interpretive Data:
Centromere B antibodies occur primarily in patients with the CREST
(calcinosis, Raynaud's phenomenon, esophageal hypomotility,
sclerodactyly, telangiectasia) syndrome variant of scleroderma.
Centromere B antibodies are seen in up 50% or more of patients with
CREST syndrome. A negative result for centromere B antibodies does
not rule out CREST syndrome. Centromere B antibodies have been
described in some patients with primary biliary cirrhosis,
rheumatoid arthritis, or lupus erythematosus.
The centromere B antibodies assay does not detect all centromere antibodies that may be seen on the ANA using immunofluorescence.
The centromere B antibodies assay does not detect all centromere antibodies that may be seen on the ANA using immunofluorescence.
Comments:
New assay introduced February 25, 2013.
Methodology:
Multiplex flow immunoassay
Sample Processing:
Centrifuge at a speed and time necessary to get barrier separation
of plasma/serum and cells within 1 hour of collection. Send specimen
in original tube. Do Not transfer to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample Storage:
Refrigerate.
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
Transport Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal
bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.