|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Plasma Separator Tube 4.5 mL|
Propylene glycol toxicity range not well defined but clinical toxicity more likely if plasma concentration exceed 100 mg/dL.
Ethylene glycol 10 mg/dL or greater
Propylene glycol 100 mg/dL or greater
The glycols by gas chromatography tests may be ordered if there is an interference with the "Ethylene Glycol, Rapid Assay" test or if quantitation of propylene glycol is needed. This procedure individually quantitates ethylene glycol and propylene glycol. Ethylene glycol is commonly found in many automobile antifreezes. Propylene glycol is found in some intravenous drug formulations as a solvent/diluent (e.g., diazepam, lorazepam, etomidate, and phenytoin) and is also found in a small number of automobile antifreezes (e.g., Sierra).
References: (1) Wilson KC, Reardon C, Theodore AC, and Farber HW. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observation pilot study. Chest 128: 1674-1681, 2005. (2) Eder AF et al. Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis. Clin Chem 44: 168-177, 1998. (3) Juenke JM et al. Rapid and specific quantification of ethylene glycol levels: adaptation of a commercial enzymatic assay to automated chemistry analyzers. Am J Clin Pathol 136: 318-324, 2011. (3) Lynd LD et al. An evaluation of the osmole gap as a screening test for toxic alcohol poisoning. BMC Emerg Med 8: 5, 2008. Profile result codes: GLYC, PGLY
Alcohols Panel (Methanol, Ethanol, Isopropanol, Acetone), Plasma
Ethanol/Volatiles Screen (EVS), Plasma
Ethylene Glycol Rapid Assay, Plasma