Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and 3

Label Mnemonic:	PEMPHI PAN
Epic code:	LAB8711
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 2 mL serum
Absolute Minimum: 0.5 mL serum

Rejection Criteria:

Hemolyzed or lipemic specimens.

Turn Around Time:

4-9 days upon receipt at reference laboratory

Reference Range:

By report

Comments:

This is the preferred panel for initial assessment and disease monitoring in IgG-variant pemphigus. Pemphigus vulgaris and pemphigus foliaceus are the most common types of pemphigus with blistering and erosive disease affecting skin and mucous membranes.

Panel components include antibody testing for IgG epithelial cell surface and IgG desmoglein 1 and 3.

To screen for pemphigus along with other possible immunobullous diseases, order concurrently with Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG and IgA, BP180 and BP230.

Methodology:

Semi-Quantitative Complement Fixation/Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

CPT Code:

88346, 88350, 83516 x2