Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, IgG & IgA, BP180 & BP230

Label Mnemonic:	PGOID PAN
Epic code:	LAB8713
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 2 mL serum
Absolute Minimum: 0.5 mL serum

Rejection Criteria:

Hemolyzed or lipemic specimens.

Turn Around Time:

4-9 days upon receipt at reference laboratory

Comments:

This is the preferred antibody panel for initial diagnostic assessment and disease monitoring in pemphigoid, epidermolysis bullosa acquisita, and linear IgA bullous dermatosis. Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita, and linear IgA bullous dermatosis present with blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes.

Panel components include IgG and IgA epithelial BMZ antibodies and IgG bullous pemphigoid BP 180 & 230 antigens.

To screen for pemphigoid along with other possible immunobullous diseases, order concurrently with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3.

Methodology:

Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

CPT Code:

88346, 88350 x3, 83516 x2