Rapid Plasma Reagin (RPR) with Reflex Confirmation

Label Mnemonic:	RPRP
Epic code:	LAB8647
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Serum

Collection Medium:

BD Gold SST 5 mL Vacutainer

Minimum:

5 mL serum from a BD Gold SST tube

Delivery Instructions:

Store and ship frozen.

Turn Around Time:

1 day

Reference Range:

Negative

Comments:

This testing consists of RPR with reflex to titer and TP-PA confirmation. Additional charges apply if TP-PA confirmation is performed.

This is generally not the preferred test for syphilis screening but may be indicated in some clinical situations. Syphilis Total Antibodies with Reflex Confirmation (LAB8631) is recommended for routine syphilis testing.

Test Limitations:

The assay is unaffected by icterus < 66 mg/dL, hemolysis (Hb < 500 mg/dL), or lipemia < 2000 mg/dL). RPR assay interference resulting in false positive results may occur with cross-reacting antibodies from patients diagnosed with systemic lupus erythematosus, malaria, autoimmune disease, viral pneumonia, and people who have been recently vaccinated (including vaccines for SARS-CoV-2). RPR results should be interpreted in conjunction with patient history, risk factors, and other syphilis testing.

Methodology:

Multiplex flow immunoassay

CPT Code:

86592