Quad Screen - Iowa Maternal Screening
Label Mnemonic: QUADIMS
Epic Lab Code: LAB8340
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Specimen Instructions:
Collect in second trimester between 15 weeks - 20 weeks 6 days. Dating by LMP or ultrasound (preferred).

Patient weight (kg), race, last menstrual period date, number of fetuses, ultrasound date, crown rump length (CRL) in mm and biparietal distance (BPD) in mm at time of ultrasound required. Also note if the patient is taking insulin for diabetes and whether the patient or her partner had a neural tube defect (NTD) or if either has had a previous pregnancy with a NTD. If IVF pregnancy, the age of the egg donor is required.

Refrigerate specimen if not transported within 24 hours of collection to reference laboratory.
Collection Medium:
Red top tube 5 mL (Clot Activator)
3 mL whole blood in Red Top Tube or 1 mL serum
Rejection Criteria:
Plasma or specimen older than 9 days. Sample not collected within the required gestational age range.
Delivery Instructions:
Deliver to laboratory after collection.
Turn Around Time:
3-5 days upon receipt at reference laboratory
Reference Range:
By report - AFP, hCG, Estriol, and Inhibin A calculated Multiples of the Median (MoMs) based on gestational age.
Second trimester screening test for DS, T18, and open NTD (spina bifida). If twin pregnancy, order NTD Screen - Iowa Maternal Screening, LAB3841.
Quantitative Chemiluminescent Immunoassay
CPT Code:
82105, 84702, 82677, 86336