NTD Screen - Iowa Maternal Screening

Label Mnemonic:	NTDIMS
Epic code:	LAB8341
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Specimen Instructions:

Collect at 15 weeks-20 weeks 6 days (dating by ultrasound).

Patient weight (kg), race, ultrasound date, crown rump length (CRL) in mm and Biparietal Distance (BPD) in mm at time of ultrasound required. If IVF pregnancy, the age of the egg donor is required.

Provide number of fetuses. This test is appropriate for assessing NTD risk in twin pregnancy.

Also note if the patient is taking insulin for diabetes and whether the patient or her partner had a neural tube defect (NTD) or if either has had a previous pregnancy with a NTD.

Refrigerate specimen if not transported within 24 hours of collection to reference laboratory.

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

3 mL whole blood in Red Top Tube or 1 mL serum

Rejection Criteria:

Plasma or specimen older than 9 days. Sample not collected within the required gestational age range.

Delivery Instructions:

Deliver to laboratory after collection.

Turn Around Time:

3-5 days upon receipt at reference laboratory

Reference Range:

By report - AFP calculated Multiple of the Median (MoM) based on gestational age.

Comments:

Second trimester screening test for open NTD (spina bifida).

This test is appropriate for those women who have already had testing or screening for Down syndrome or Trisomy 18, either by chorionic villus sample (CVS) or the First Trimester Screen Only - Iowa Maternal Screening (LAB8342). Note if the patient already had a Down Syndrome Risk assessment by either biochemical or DNA methods.

Methodology:

Quantitative Chemiluminescent Immunoassay

CPT Code:

82105