NMDA Receptor Antibodies

Label Mnemonic:	NMDAS
Epic code:	LAB7734
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

2 mL serum in a red top tube
Absolute Minimum: 0.15 mL serum

Rejection Criteria:

CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Turn Around Time:

1-8 days upon receipt at reference laboratory.

Reference Range:

< 1:10

Interpretive Data:

Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response, therefore clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

Note: If NMDA antibody IgG is positive, then an NMDA antibody IgG titer will be added. Additional charges.

Methodology:

Semi-Quantitative Indirect Fluorescent Antibody

CPT Code:

86255 NMDA; if reflexed add 86256 NMDA titer