Pepsinogen II
Label Mnemonic: PEPSIN2
Epic Lab Code: LAB5692
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Plasma or Serum
Collection Medium:
Pink top tube 6 mL (K2-EDTA)
Alternate Collection Media:
Red top tube 5 mL (Clot Activator)
Preferred Minimum: 3 mL K2 EDTA plasma or serum
Absolute Minimum: 1 mL K2 EDTA plasma or serum
Turn Around Time:
5-7 working days
Reference Range:
Up to 22 ng/mL
Interpretive Data:
The Pepsinogens are gastric acid protease zymogens. They are divided into two distinct immunochemical groups: Pepsinogen I and II. Pepsinogen II is one of four aspartic proteinases: PG I, PG II, Cathepsin E and D. Pepsinogen II is produced primarily in the Oxyntic gland mucosa of the stomach, the gastric antrum and the duodenum. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen II has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Unlike Pepsinogen I, Pepsinogen II is not normally found in the urine. Patients with pernicious anemia have low to non-detectable levels of Pepsinogen I but normal levels of Pepsinogen II. Pepsinogen II levels are slightly elevated in gastric ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels.
Patient should be fasting 10 - 12 hours prior to collection of specimen. Antacids or other medications affecting stomach acidity or gastrointestinal motility should be discontinued, if possible, for at least 48 hours prior to collection.
Radioimmunoassay (RIA)
CPT Code:
See Additional Information:
Fasting Specimen Requirements