Neuromyelitis Optica/Aquaporin-4-IgG

Label Mnemonic:	NMOIGGS
Epic code:	LAB8502
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Specimen Instructions:

Include relevant clinical information, name, phone number, mailing address, and e-mail address (if applicable) of ordering physician.

Collection Medium:

	and
Red top tube 5 mL (Clot Activator)	and	Red top tube 5 mL (Clot Activator)

Minimum:

Collect in TWO full red top tubes.
Preferred Minimum: 4.0 mL serum
Absolute Minimum: 2.0 mL serum

Delivery Instructions:

Deliver to laboratory immediately after collection.

Turn Around Time:

5 days upon receipt at reference laboratory

Reference Range:

Negative

Comments:

Useful For:
*Diagnosis of a neuromyelitis optica spectrum disorder
*Diagnosis of autoimmune AQP4 channelopathy
*Distinguishing NMOSD from multiple sclerosis early in the course
of disease

ALGORITHM: When the results of this assay require further evaluation, the titer assay will be performed at an additional charge.

Methodology:

Fluorescence-Activated Cell Sorting Assay (FACS)

CPT Code:

86255
86256-NMO/AQP4-IgG FACS titer (if appropriate)

See Additional Information:
Specimens Requiring Immediate Delivery