Chitotriosidase (CHITO) for Gaucher clinical drug monitoring

Label Mnemonic:	GENCHITO
Epic code:	LAB2845
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Pediatric Minimum: 2.0 mL serum
Absolute Pediatric Minimum: 1.0 mL serum

Rejection Criteria:

Specimens must be received at reference laboratory within 4 days of specimen collection; do not collect on Fridays, holidays, day before a holiday, or weekends.

Turn Around Time:

1-2 weeks upon receipt at reference laboratory

Reference Range:

4 - 120 nmoles/hr/mL: median=22 nmoles/hr/mL

Comments:

The Chitotriosidase fluorometric enzyme assay uses 4-methylumbelliferyl-beta-D-triacetylchitotrioside as substrate.

Testing used for patients on Cerezyme (part of Gaucher Disease clinical drug monitoring including ACE, TRAP and CHITO).

Methodology:

Fluorometric enzyme assay

CPT Code:

82657