|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
Absolute Minimum: 0.3 mL CSF from CSF tube #2
A low L:P ratio (disproportionately elevated pyruvic acid) may indicate an inherited disorder of pyruvate metabolism. Defects of the pyruvate dehydrogenase complex result in L:P ratios <10.
The L:P ratio is characteristically normal in other patients. An artifactually high ratio can be found if the patient is acutely ill.
Correct specimen collection and handling is crucial to achieve reliable results.
Pyruvic acid levels alone have little clinical utility. Abnormal concentrations of pyruvic acid, and lactate-to-pyruvate (L:P) ratios, are not diagnostic for a particular disorder but must be interpreted in the context of the patient's clinical presentation and other laboratory studies.
For the L:P ratio, both analytes should be determined on the same specimen.
When comparing blood and cerebrospinal fluid (CSF) L:P ratios, blood and CSF specimens should be collected at the same time.
Pyruvic Acid, Blood