Erythropoietin
Label Mnemonic: EPO
Epic Lab Code: LAB3082
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator)
Alternate Collection Media:
Plasma Separator Tube 4.5 mL or Call laboratory for additional acceptable specimen collection containers.
Minimum:
Preferred Minimum: 1.0 mL serum
Absolute Minimum: 0.5 mL serum

Call Specimen Control at 319-356-3527 for additional specimen types.
If additional tests are going to be ordered, extra red top tubes may be needed. Please call the lab for consultation.
Rejection Criteria:
Bone Marrow aspirate. EDTA plasma specimens and hemolyzed specimens.
Delivery Instructions:
Deliver to laboratory immediately after collection.
Turn Around Time:
4 working days upon receipt at reference laboratory
Reference Range:
Normal serum concentrations of erythropoietin for 95% of individuals with normal hematocrits range from 4-27 mU/mL. As the hematocrit is lowered by iron deficiency, aplastic or hemolytic anemia, the concentration of erythropoietin increases as shown in the graph below. In the absence of anemia, elevated concentrations are seen in renal tumors, as a manifestation of renal transplant rejection, and in secondary polycythemia. Low values may be observed in hemochromatosis. Decreased erythropoietin concentrations with an elevated hematocrit are observed in patients with polycythemia rubra vera, and with a decreased hematocrit in patients with HIV infection who are receiving AZT. Patients on AZT who have anemia and erythropoietin concentrations of less than or equal to 500 mU/mL, may benefit from therapy with recombinant EPO (NEJM 322:1488-1493, 1990). EXPECTED ERYTHROPOIETIN CONCENTRATIONS IN PATIENTS WITH UNCOMPLICATED ANEMIA ERYTHROPOIETIN (mU/mL) 100,000| | | | 10,000|............. | ............. | ............. | ............. 1,000| ............. | ............. | ............. | ............. 100| ............. | ............. | ............. 10| ............. | ............. |______________________________________________ 10 20 30 40 50 60 70 (HEMATOCRIT %) Source: Caro J and Erslev AJ. Erythropoietin assays and their use in the study of anemias. Contrib Nephrol 1988; 66:54-62. Review.
Methodology:
Quantitative Chemiluminescent Immunoassay
CPT Code:
82668
 
See Additional Information:
Specimens Requiring Immediate Delivery