|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Light Blue top tube 2.7 mL (Na Citrate)|
Absolute Minimum: 1.0 mL platelet poor plasma (light blue tube top).
Plasminogen activator inhibitor-1 (PAI-1) is an inhibitor of tissue plasminogen activator (t-PA), a key enzyme in fibrinolysis. PAI- 1 is synthesized by endothelial cells, platelets, and hepatocytes. Three forms of PAI-1 have been identified. The first form is the active form, while the other two forms are inactive and latent. The main function of PAI-1 in hemostasis is to inhibit t-PA. As PAI-1 levels increase, active levels of t-PA decrease, causing impaired fibrinolytic function. Elevated levels of PAI-1 have been observed in deep-vein thrombosis and myocardial infarction, as well as in normal pregnancy and sepsis. One unit of PAI-1 activity is defined as the amount of PAI-1 that inhibits one international unit of t-PA, as calibrated against the international standard for t-PA. This assay should be used for the quantitative determination of active PAI-1 in human plasma. This may be useful in the diagnosis of thrombotic disease.
Specimens Requiring Immediate Delivery