Leukocyte Adhesion Deficiency Panel
Label Mnemonic: LAD
Epic Lab Code: LAB7571
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Commercial Mail-out Laboratory
5231 RCP
Whole Blood
Collection Medium:
Green top tube 4 mL (Na Heparin) Green top tube 4 mL (Na Heparin)
Alternate Collection Media:
Light Green top tube (Lithium Heparin)
Draw TWO 4 mL green (sodium or lithium heparin) to send 5 mL preferred Minimum. Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts.
Rejection Criteria:
Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.
Delivery Instructions:
Deliver to laboratory immediately after collection. Specimen must be analyzed within 48 hours of collection.
Turn Around Time:
1-3 days upon receipt in reference laboratory
Reference Range:
Component Reference Interval % CD11b 93-100% % CD15 93-100% % CD18 93-100%
Interpretive Data:
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.
Semi-Quantitative Flow Cytometry
CPT Code:
86356 CD11b; 86356 CD15; 86356 CD18
See Additional Information:
Specimens Requiring Immediate Delivery