Amino Acids, Quantitative
Label Mnemonic: AAQTU
Epic Lab Code: LAB355
Downtime Form: A-1a Miscellaneous Request
Commercial Mail-out Laboratory
5231 RCP
356-8593
Specimen(s):
Random Urine
Specimen Instructions:
Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information. Patient's age is required on request form for processing.
Collection Medium:
Yellow top round bottom tube (no additive)
Minimum:
2 mL aliquot from random urine
Delivery Instructions:
Deliver to laboratory immediately after collection.
Testing Schedule:
Tests performed Monday through Friday only.
Turn Around Time:
3 days upon receipt at reference laboratory (not reported on Saturday or Sunday)
Reference Range:
Age Groups Urine Amino Acid < or = 13-35 3-6 7-8 9-17 > or = Reference Values 12 Mo Mo Y Y Y 18 Y (nmol/mg creatine) (n=515) (n=210) (n=197) (n=74) (n=214) (n=835) ------------------------------------------------------------------------ Phosphoserine <1 <1 <1 <1 <1 <1 Phosphoethanolamine 15-341 33-342 19-164 12-118 <88 <48 Taurine 37-8300 64-3255 76-3519 50-2051 57-2235 24-1531 Asparagine 25-1000 62-884 28-412 38-396 22-283 25-238 Serine 18-4483 284-1959 179-1285 153-765 105-846 97-540 Hydroxyproline <2536 <89 <46 <19 <22 <15 Glycine 362- 627- 412- 449- 316- 229- 18614 6914 5705 4492 4249 2989 Glutamine 139- 263- 152- 164- 188- 93- 2985 2979 1325 1125 1365 686 Aspartic Acid <64 <56 <30 <9 <11 <10 Ethanolamine 282- 256- 193- 137- 158- 95- 3782 947 643 564 596 471 Histidine 145- 427- 230- 268- 134- 81- 3833 3398 2635 2147 1983 1128 Threonine 25-1217 55-763 30-554 25-456 37-418 31-278 Citrulline <72 <57 <14 <9 <14 <12 Sarcosine <75 <12 <9 <2 <3 <3 Beta-Alanine <219 <92 <25 <25 <49 <52 Alanine 93-3007 101-1500 64-1299 44-814 51-696 56-518 Glutamic Acid <243 12-128 <76 <39 <62 <34 1-Methylhistidine 17-419 18- 10- 19- 12- 23- 1629 1476 1435 1549 1339 3-Methylhistidine 88-350 86-330 56-316 77-260 47-262 70-246 Argininosuccinic <77 <48 <37 <24 <69 <15 Acid Carnosine 27-1021 16-616 18-319 <161 <109 <35 Anserine <277 <820 <398 <141 <369 <38 Homocitrulline <295 11-158 <71 <62 <33 <30 Arginine 10-560 20-395 14-240 <134 <153 <114 Alpha-aminoadipic 10-275 15-324 10-135 <84 <76 <47 Acid Gamma Amino-n- <25 <13 <11 <6 <5 <5 butyric Acid Beta- 18-3137 <980 15-1039 24-511 11-286 <301 aminoisobutyric Acid Alpha-amino-n- <63 <56 <38 <30 <31 <19 butyric Acid Hydroxylysine <150 <57 <34 <26 <31 <12 Proline 28-2029 <119 <78 <20 <28 <26 Ornithine <265 <70 <44 <17 <18 <25 Cystathionine <302 <56 <26 <18 <44 <30 Cystine 12-504 11-133 <130 <56 <104 10-98 Lysine 19-1988 25-743 14-307 17-276 10-240 15-271 Methionine <41 <41 <25 <23 <20 <16 Valine 11-211 11-211 <139 16-91 <75 11-61 Tyrosine 39-685 38-479 23-254 22-245 12-208 15-115 Isoleucine <86 <78 <62 <34 <28 <22 Leucine <200 15-167 12-100 13-73 <62 <51 Phenylalanine 14-280 34-254 20-150 21-106 11-111 13-70 Tryptophan 14-315 14-315 10-303 10-303 15-229 18-114 Allo-isoleucine <29 <10 <8 <8 <8 <7
Interpretive Data:
When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, elements of differential diagnosis, recommendations for additional biochemical testing and in vitro confirmatory studies (enzyme assay, molecular analysis), name and phone number of key contacts who may provide these studies at the reference laboratory or elsewhere, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.
Comments:
Useful For:
Suggests clinical disorders or settings where the test may be helpful evaluating patients with possible inborn errors of metabolism

May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), Quantitative

Includes quantitation of the following amino acids: taurine, threonine, serine, asparagine, glutamic acid, glutamine, proline, glycine, alanine, citrulline, a-aminoadipic acid, a-amino-n-butyric acid, valine, cystine, cystathionine, methionine, isoleucine, leucine, tyrosine, phenylalanine, b-alanine, b-aminoisobutyric acid, ornithine, lysine, 1-methylhistidine, histidine, 3-methylhistidine, carnosine, argininosuccinic acid, allo-isoleucine, homocitrulline, and arginine.
CPT Code:
82139