Cardiac CRP
Label Mnemonic: HSCRP
Epic Lab Code: LAB150
Downtime Form: A-1a General Laboratory Requisition
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL plasma from light green top tube or 1 Microtainer®
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Quintile CRP mg/L Risk of Coronary Heart Disease 1 < 0.7 Lowest Risk 2 0.7 - 1.1 Low Risk 3 1.2 - 1.9 Moderate Risk 4 2.0 - 3.8 High Risk 5 3.9 - 15.0 Highest Risk > 15.0 mg/L: When Cardiac CRP is greater than 15.0 mg/L, risk analysis may be confounded by recent or acute inflammatory disease. Therefore, the risk for coronary heart disease cannot be provided for this patient. A repeat specimen, taken two weeks after resolution of any acute inflammatory condition, may allow provision of coronary risk information. References: 1. Ridker, P.M. et al. 2000. N Engl J Med. 342;836-843. 2. Rifai N. and Ridker, P.M. 2001. Clin Chem. 47; 403-411. 3. Ridker, P.M. et al. 2002. N Engl J Med. 347;1557-1565.
Interpretive Data:
Cardiac CRP is intended for the measurement of basal levels of C- reactive protein (CRP) as assessment of risk of developing of cardiovascular disease or ischemic events. Measurement of cardiac CRP in hospitalized patients and/or those with active systemic inflammatory or infectious processes is NOT clinically useful and will generally produce results that exceed the upper limit of the cardiac CRP assay.

Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 600 (approximate triglycerides concentration: 1200 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL).
Test Limitations:
Significantly decreased CRP values may be obtained from samples taken from patients who have been treated with carboxypenicillins.
Methodology:
Turbidimetric method utilizing latex particles coated with CRP monoclonal antibodies.
CPT Code:
86141
 
See also:
C-Reactive Protein (CRP), Plasma