Heistad Lab ∣ The University of Iowa

Selected Recent Publications

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Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.
Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, Heistad DD. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):466-74. PMID: 26769049


Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.
Hajj GP, Chu Y, Lund DD, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Hameed T, Doshi H, Chen B, Leinwand LA, Song LS, Heistad DD, Weiss RM. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1653-62. PMID: 25997932


Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase.
El Accaoui RN, Gould ST, Hajj GP, Chu Y, Davis MK, Kraft DC, Lund DD, Brooks RM, Doshi H, Zimmerman KA, Kutschke W, Anseth KS, Heistad DD, Weiss RM. Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1302-13. PMID: 24610917


Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse models.
Weiss RM, Miller JD, Heistad DD. Circ Res. 2013 Jul 5;113(2):209-22. PMID: 23833295

Osteoprotegerin inhibits aortic valve calcification and preserves valve function in hypercholesterolemic mice.
Weiss RM, Lund DD, Chu Y, Brooks RM, Zimmerman KA, El Accaoui R, Davis MK, Hajj GP, Zimmerman MB, Heistad DD. PLoS One. 2013 Jun 6;8(6):e65201. PMID: 23762316

Pioglitazone attenuates valvular calcification induced by hypercholesterolemia.
Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):523-32. PMID: 23288158


Calcific aortic valve stenosis: methods, models, and mechanisms.
Miller JD, Weiss RM, Heistad DD. Circ Res. 2011 May 27;108(11):1392-412. doi: 10.1161/CIRCRESAHA.110.234138.
Review. PMID: 21617136


Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.
Miller JD, Weiss RM, Serrano KM, Castaneda LE, Brooks RM, Zimmerman K, Heistad DD. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2482-6. doi: 10.1161/ATVBAHA.110.211029. PMID: 20864669


Serotonin produces monoamine oxidase-dependent oxidative stress in human heart valves.
Peña-Silva RA, Miller JD, Chu Y, Heistad DD. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1354-60. doi: 10.1152/ajpheart.00570.2009. PMID: 19666839

Biventricular adaptation to volume overload in mice with aortic regurgitation.
Berry CJ, Miller JD, McGroary K, Thedens DR, Young SG, Heistad DD, Weiss RM. J Cardiovasc Magn Reson. 2009 Aug 11;11:27. doi: 10.1186/1532-429X-11-27. PMID: 19671155

Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.
Miller JD, Weiss RM, Serrano KM, Brooks RM 2nd, Berry CJ, Zimmerman K, Young SG, Heistad DD. Circulation. 2009 May 26;119(20):2693-701. doi: 10.1161/CIRCULATIONAHA.108.834614. PMID: 19433756


Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans.
Miller JD, Chu Y, Brooks RM, Richenbacher WE, Peña-Silva R, Heistad DD. J Am Coll Cardiol. 2008 Sep 2;52(10):843-50. doi: 10.1016/j.jacc.2008.05.043. PMID: 18755348


Calcific aortic valve stenosis in old hypercholesterolemic mice.
Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Circulation. 2006 Nov 7;114(19):2065-9. PMID: 17075015