IgG Subclasses

Label Mnemonic:	IGGSUB
Epic code:	LAB3409
Downtime form:	Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Serum or Plasma

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred minimum: 2.0 mL serum
Absolute minimum: 0.45 mL serum

Turn Around Time:

3 days upon receipt at reference laboratory

Reference Range:

Immunoglobulin G Subclass 1:       Immunoglobulin G Subclass 2:
Cord blood: 435-1084 mg/dL         Cord blood: 143-453 mg/dL
0-2 months: 218-498 mg/dL          0-2 months: 40-167 mg/dL
3-5 months: 143-394 mg/dL          3-5 months: 23-147 mg/dL
6-8 months: 190-388 mg/dL          6-8 months: 37-60 mg/dL
9-23 months: 288-880 mg/dL         9-23 months: 30-327 mg/dL
2 years: 170-950 mg/dL             2 years: 22-440 mg/dL
3-4 years: 290-1065 mg/dL          3-4 years: 28-315 mg/dL
5-6 years: 330-1065 mg/dL          5-6 years: 57-345 mg/dL
7-8 years: 225-1100 mg/dL          7-8 years: 42-375 mg/dL
9-10 years: 390-1235 mg/dL         9-10 years: 61-430 mg/dL
11-12 years: 380-1420 mg/dL        11-12 years: 73-455 mg/dL
13-14 years: 165-1440 mg/dL        13-14 years: 71-460 mg/dL
15 years & over: 240-1118 mg/dL    15 years & over: 124-549 mg/dL

Immunoglobulin G Subclass 3:       Immunoglobulin G Subclass 4:
Cord blood: 27-146 mg/dL           Cord blood: 1-47 mg/dL
0-2 months: 4-23 mg/dL             0-2 months: 1-33 mg/dL
3-5 months: 4-70 mg/dL             3-5 months: 1-14 mg/dL
6-8 months: 12-62 mg/dL            6-8 months: 1-16 mg/dL
9-23 months: 13-82 mg/dL           9-23 months: 1-65 mg/dL
2 years: 4-69 mg/dL                2 years: 0-120 mg/dL
3-4 years: 4-71 mg/dL              3-4 years: 0-90 mg/dL
5-6 years: 8-126 mg/dL             5-6 years: 2-116 mg/dL
7-8 years: 9-107 mg/dL             7-8 years: 0-138 mg/dL
9-10 years: 10-98 mg/dL            9-10 years: 1-95 mg/dL
11-12 years: 16-194 mg/dL          11-12 years: 1-153 mg/dL
13-14 years: 12-178 mg/dL          13-14 years: 2-143 mg/dL
15 years & over: 21-134 mg/dL      15 years & over: 1-123 mg/dL

Interpretive Data:

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the nephelometric method of quantitation for total IgG.

Comments:

Ordering Recommendation: Do not order for total IgG measurements. Secondary test in suspected immunoglobulin deficiency. Do not order before IgG, IgA, and IgM measurements are performed.

Methodology:

Quantitative Nephelometry

CPT Code:

82787(x4) IgG subclasses (1,2,3,4)

See also:
Immunoglobulin G (IgG), Individual Quant, Plasma