Octreotide (Sandostatin)
Order Code: OCTREO
Epic Lab Code: LAB3747
Order Form: A-1a Miscellaneous Request or Epic Req
Commercial Mail-out Laboratory
6240 RCP
356-3527
Specimen:
Plasma
Collection Medium:
GI preservative collection tube
Minimum:
1 mL plasma from a Special Z-GI preservative collection tube obtained from reference laboratory. Mailouts has these tubes, call 356-8593.
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection period is completed.
Analytic Time:
1 week upon receipt at reference laboratory
Reference Range:
Long-acting repeatable (LAR) dose-response levels: mean octreotide level + or - 2 SD for patients on octreotide LAR for 3 or more months (steady-state). The following represent trough levels measured immediately before an injection of LAR. 10 mg/month: 1,153 + or - 748 pg/ml 20 mg/month: 2,518 + or - 1,020 pg/ml 30 mg/month: 5,241 + or - 3,004 pg/ml 60 mg/month: 10,926 + or - 5,530 pg/ml
Comments:
Contact Commercial Mailouts at 356-8593 to obtain collection tubes for this testing. No other specimen collection container is acceptable by the reference laboratory. This test is useful only for those patients being treated with octreotide acetate. No special preparation is needed for this test. For optimal results, blood for this test should be drawn immediately before the patient's next injection of octreotide LAR (trough levels). Clinical Significance: Octreotide (Sandostatin, Novartis Pharmaceutical Company) is used for the control of symptoms associated with functional neuroendocrine tumors. Frequent measurement of the octreotide levels may be useful in guiding therapy in patients with poorly controlled symptoms or those patients experiencing tumor growth during LAR therapy. Octreotide levels in blood need to be in a specific range to be effective. Measuring octreotide immediately prior to the monthly LAR injection will determine trough levels of the drug in your blood.
Methodology:
Octreotide is measured by direct radioimmunoassay. There is no cross-reactivity with native somatostatin-14 or somatostatin-28. The also is no cross-reactivity with lanreotide, and this test should not be used to measure blood levels of this drug.
CPT Code:
83519