Homovanillic Acid (HVA)
| Order Code: | HVA24 |
| Epic Lab Code: | LAB7450 |
| Order Form: | A-1a Miscellaneous Request or Epic Req |
Commercial Mail-out Laboratory
6240 RCP
356-3527
6240 RCP
356-3527
Specimen:
Urine
Collection Medium:
) |
| Urine - 24 hour/timed plastic urine container |
Minimum:
Preferred Minimum: 4 mL from a well-mixed 24 hr urine
collection.
Absolute Minimum: 1 mL from a well-mixed 24 hr urine collection.
Abstain from medications for 72 hours prior to collection.
Absolute Minimum: 1 mL from a well-mixed 24 hr urine collection.
Abstain from medications for 72 hours prior to collection.
Rejection Criteria:
Specimens types other than urine.
Specimen
Instructions:
Refrigerate 24-hour specimens during collection. Refrigeration is the
preferred method of preservation.
All four tests may be done on same collection.
All four tests may be done on same collection.
Analytic Time:
4 working days upon receipt at reference laboratory
Reference Range:
Components Age Ref. Interval
HVA 18 years and older 0.0-15.0 mg/d
The HVA-to-creatinine ratio will be reported when the
patient is under 18 years or the urine volume is less
than 400 mL/24 hours.
HVA 0-2 years 0-42 mg/g crt
3-5 years 0-22 mg/g crt
6-17 years 0-15 mg/g crt
18 years and older 0-8 mg/g crt
Creatinine-24 hr
Male
3-8 years 140-700 mg/d
9-12 years 300-1300 mg/d
13-17 years 500-2300 mg/d
18-50 years 1000-2500 mg/d
51-80 years 800-2100 mg/d
81 years and older 600-2000 mg/d
Female
3-8 years 140-700 mg/d
9-12 years 300-1300 mg/d
13-17 years 400-1600 mg/d
18-50 years 700-1600 mg/d
51-80 years 500-1400 mg/d
81 years and older 400-1300 mg/d
Interpretive Data:
Homovanillic acid (HVA) results are expressed as a ratio to creatinine
excretion (mg/g cr). HVA mass per day (mg/d) is not reported on
specimens from patients younger than 18 years of age, for random
specimens, urine collection periods other than 24 hours, or for urine
volumes less than 400 mL/d. No reference interval is available for
results reported in units of mg/L.
Comments:
If screening for Neuroblastoma, the following tests are suggested:
CAT24 (Catecholamines, Fractionated; Dopamine is included), HVA24
(Homovanillic Acid), MET24 (Metanephrines), VMA24 (Vanillylmandelic
Acid).
Moderately elevated HVA (homovanillic acid) may be caused by a variety of factors such as essential hypertension, intense anxiety, intense physical exercise, and numerous drug interactions (including some over- the-counter medications and herbal products).
Medications which may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet®), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet®), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.
Moderately elevated HVA (homovanillic acid) may be caused by a variety of factors such as essential hypertension, intense anxiety, intense physical exercise, and numerous drug interactions (including some over- the-counter medications and herbal products).
Medications which may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet®), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet®), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predictable.
Methodology:
High Performance Liquid Chromatography
CPT Code:
83150
See also:
Catecholamines, Fractionated, Urine
Metanephrines, Urine
Vanillylmandelic Acid (VMA), Urine
Catecholamines, Fractionated, Urine
Metanephrines, Urine
Vanillylmandelic Acid (VMA), Urine
See Additional Information:
Urine Tests Requiring Preservatives, Refrigeration or Special Containers
Urine Tests Requiring Preservatives, Refrigeration or Special Containers