Leukocyte Adhesion Deficiency Panel

Label Mnemonic:	LAD
Epic code:	LAB7571
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Commercial Mailout Laboratory
6240-8 RCP
356-8593

Specimen(s):

Whole Blood

Collection Medium:

	and
Green top tube 4 mL (Na Heparin)	and	Green top tube 4 mL (Na Heparin)

Alternate Collection Media:

Light Green top tube (Lithium Heparin)

Minimum:

Draw TWO 4 mL green (sodium or lithium heparin) to send 5 mL preferred Minimum. Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts.

Rejection Criteria:

Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.

Delivery Instructions:

Deliver to laboratory immediately after collection. Specimen must be analyzed within 48 hours of collection.

Turn Around Time:

1-3 days upon receipt in reference laboratory

Reference Range:

Component      Reference Interval
 % CD11b             93-100%    
 % CD15              93-100% 
 % CD18              93-100%

Interpretive Data:

The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

Methodology:

Semi-Quantitative Flow Cytometry

CPT Code:

86356 CD11b; 86356 CD15; 86356 CD18

See Additional Information:
Specimens Requiring Immediate Delivery