C-Reactive Protein, High-Sensitivity, Plasma

C-Reactive Protein, High-Sensitivity

Order Code:	HSCRP
Epic Lab Code:	LAB150
Order Form:	A-1a General Lab or Epic Req

Chemistry
6240 RCP
356-3527

Specimen:

Plasma

Collection Medium:

Plasma Separator Tube

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3 mL plasma from light green top tube or 1 microtainer

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Reference Range:

Quintile CRP mg/L Risk of Coronary Heart Disease 1 < 0.7 Lowest Risk 2 0.7 - 1.1 Low Risk 3 1.2 - 1.9 Moderate Risk 4 2.0 - 3.8 High Risk 5 3.9 - 15.0 Highest Risk > 15.0 mg/L: When Highly Sensitive CRP is greater than 15.0 mg/L, risk analysis may be confounded by recent or acute inflammatory disease. Therefore, the risk for coronary heart disease cannot be provided for this patient. A repeat specimen, taken two weeks after resolution of any acute inflammatory condition, may allow provision of coronary risk information. References: 1. Ridker, P.M. et al. 2000. N Engl J Med. 342;836-843. 2. Rifai N. and Ridker, P.M. 2001. Clin Chem. 47; 403-411. 3. Ridker, P.M. et al. 2002. N Engl J Med. 347;1557-1565.

Interpretive Data:

Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 500 (approximate triglycerides concentration: 1000 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL).

Test Limitations:

Significantly decreased CRP values may be obtained from samples taken from patients who have been treated with carboxypenicillins.

Methodology:

Turbidometric method utilizing latex particles coated with CRP monoclonal antibodies.

CPT Code:

86141