Metanephrines, Free
Label Mnemonic: | METP |
Epic code: | LAB3587 |
Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Plasma
Specimen
Instructions:
Patient Preparation: Drugs and medications may affect
results and should be discontinued for at least 72 hours prior to
specimen collection, if possible. Collection of the specimen after the
patient has rested for 15 minutes in a supine position is
recommended.
Collection Medium:
Pink top tube 6 mL (K2-EDTA) |
Minimum:
Preferred Minimum: 2 mL plasma from lavender top (EDTA) tube
Absolute Minimum: 1 mL plasma from lavender top (EDTA) tube
Absolute Minimum: 1 mL plasma from lavender top (EDTA) tube
Rejection Criteria:
Plasma separator tubes. Body fluids other than EDTA or heparinized plasma. Non-frozen specimens. Grossly hemolyzed.
Delivery Instructions:
Deliver to laboratory immediately after collection.
Turn Around
Time:
2-5 days upon receipt in reference laboratory
Reference Range:
Normetanephrine: 0.0-0.89 nmol/L
Metanephrine: 0.0-0.49 nmol/L
Metanephrine: 0.0-0.49 nmol/L
Interpretive Data:
This test is useful in the detection of pheochromocytoma, a rare
neuroendocrine tumor. The majority of patients with pheochromocytoma
have a plasma normetanephrine concentration in excess of 2.2 nmol/L
and/or a metanephrine concentration in excess of 1.1 nmol/L. Increased
concentrations of these analytes serve as confirmation for diagnosis.
Patients with essential hypertension and plasma concentrations of
normetanephrine below 0.9 nmol/L and a metanephrine concentration
below 0.5 nmol/L, can be excluded from further testing. If clinical
suspicion remains, repeat testing or testing for metanephrines in a 24-
hr. urine specimen should be considered.
Comments:
Note: Isoetharine, isoproterenol, 3,4-methylenedioxyamphetamine
(MDA), and 3,4-methylenedioxymethamphetamine (MDMA) are known to
interfere in this test.
Many drugs/medications, including over-the-counter and herbal products, can interfere with test results. Testing for all potential interactions is not possible. If the patient is taking a drug not listed as an interferent, its potential effect on test results is unknown. If test results are inconsistent with clinical evidence, drug interference should be considered. If appropriate, the patient should discontinue the potential interferent for 48-72 hours and a new sample collected for retesting.
Many drugs/medications, including over-the-counter and herbal products, can interfere with test results. Testing for all potential interactions is not possible. If the patient is taking a drug not listed as an interferent, its potential effect on test results is unknown. If test results are inconsistent with clinical evidence, drug interference should be considered. If appropriate, the patient should discontinue the potential interferent for 48-72 hours and a new sample collected for retesting.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
83835
See Additional Information:
Specimens Requiring Immediate Delivery
Specimens Requiring Immediate Delivery