Iowa Pan-Cancer Mutation Profiling
Label Mnemonic: PCMP
Epic code: LAB9476
Order form: Molecular Oncology Requisition
Supply order: Supply Order Form
Billing: Billing Policies
Specimen(s):
Formalin Fixed, Paraffin Embedded Tissue (FFPET) Fine Needle Aspirate material including; Pap and Diff quick stained slides
Collection Medium:
Tissue Block
Rejection Criteria:
Decalcified specimens will be rejected.
Turn Around Time:
7-10 days Upon receipt within laboratory
Comments:
Variants with Established Clinical Significance (Tier 1), with Potential Clinical Significance (Tier 2) and/or with Uncertain Clinical Significance (Tier 3) are reported from the 507 gene regions interrogated by the assay and that are known to be somatically altered in human cancers including some that are validated targets for therapy, either approved or in clinical trials, and or are drivers of oncogenesis. Benign and Likely Benign variants are not included but are available upon request. Sequencing includes targeted or full coding sequence depending on the gene and the spectrum of sequence variants includes substitutions, insertions, deletions (up to 42 base pairs) and copy number alterations (gene deletion or gene amplification). Additionally, biomarker information for microsatellite instability (MSI) and tumor mutation burden (TMB) are reported.

Gene List:

ABL1, ABL2, ACVR1B, AKT1*, AKT2*, AKT3*, ALK*, AMER1*, APC*, AR*, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX*, AURKA*, AURKB, AXIN1, AXIN2, AXL*, B2M, BAP1, BARD1, BCL10, BCL11B, BCL2, BCL2L1, BCL2L2, BCL6*, BCL7A, BCOR*, BCORL1, BCR, BIRC3, BLM, BMPR1A, BRAF*, BRCA1, BRCA2*, BRCC3, BRD3, BRD4, BRIP1, BTG1, BTK, BUB1B, C11orf30 (EMSY)*, CALR, CARD11*, CASP8, CBFB, CBL, CBLB, CBLC, CCND1*, CCND2*, CCND3*, CCNE1*, CD19, CD274, CD28, CD40, CD58, CD79A, CD79B, CDC73, CDH1*, CDK12, CDK4*, CDK6*, CDK8, CDKN1A, CDKN1B*, CDKN2A*, CDKN2B*, CDKN2C, CEBPA, CHD2, CHD4*, CHEK1, CHEK2, CIC, CIITA, COL1A1, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUX1, CXCR4, CYLD, DAXX*, DDR2*, DDX3X*, DDX41, DICER1, DNM2, DNMT3A, DOT1L, EBF1, EED, EFNB2, EGFR*, EGR2, EIF1AX, EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, EPHB4, ERBB2*, ERBB3*, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERG, ERRFI1, ESR1*, ETNK1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EXT1, EZH2*, FAM175A (ABRAXAS1), FAM46C (TENT5C), FAM5C (BRINP3), FANCA*, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FANCM, FAS*, FAT1*, FAT3, FBXO11, FBXW7, FGF10, FGF14, FGF19*, FGF23*, FGF3*, FGF4*, FGF6, FGFR1*, FGFR2*, FGFR3*, FGFR4*, FH, FLCN, FLT1, FLT3*, FLT4*, FOXA1*, FOXL2, FOXO1, FOXP1, FOXR2, FRS2, FUBP1, FUS, GABRA6, GATA1, GATA2*, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS*, GNB1, GPC3, GPR124 (ADGRA2), GREM1, GRIN2A, GRM3, GSK3B, H3F3A (H3-3A), HDAC4, HGF, HIF1A, HIST1H1E (H1-4), HIST1H3B (H3C2), HIST1H3C (H3C3), HLA-A, HLA-B, HLA-DRB1, HMGA2, HNF1A, HOXB13, HRAS, HSD3B1, HSP90AA1, ID3, IDH1, IDH2, IGF1R*, IGF2, IKBKE, IKZF1, IKZF2, IKZF3, IL2RG, IL7R*, INHBA, INPP4B, IRF2, IRF4, IRF8, IRS2, ITK, ITPKB, JAK1, JAK2, JAK3, JAZF1, JUN, KAT6A, KDM5A, KDM5C*, KDM6A*, KDR*, KEAP1, KEL, KIF1B, KIF5B, KIT*, KLF2, KLF4, KLHL6, KMT2A, KMT2B, KMT2C, KMT2D, KRAS*, LIFR, LMO1, LRP1B, LYN, LYST, LZTR1, MAGI2, MAML2, MAP2K1, MAP2K2, MAP2K4*, MAP3K1*, MAP3K3, MAP3K7, MAPK1, MAX, MCL1*, MDM2*, MDM4*, MECOM*, MED12, MEF2B*, MEN1, MET*, MITF*, MLH1, MLH3, MN1, MPL*, MRE11A (MRE11), MSH2, MSH3, MSH6, MTOR, MUTYH, MYB, MYBL1, MYC*, MYCL*, MYCN*, MYD88, MYH9, NBN, NCOA2, NCOR1, NF1*, NF2*, NFE2, NFE2L2, NFKBIA, NFKBIE, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NPM1*, NRAS, NSD1, NT5C2, NTHL1, NTRK1*, NTRK2*, NTRK3*, NUP214, NUP93, NUTM1, PAK3, PALB2, PARK2 (PRKN), PAX3, PAX5, PAX7, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFB, PDGFRA*, PDGFRB*, PDK1, PHF6*, PHOX2B, PIGA, PIK3C2B*, PIK3CA*, PIK3CB*, PIK3CD, PIK3CG, PIK3R1, PIK3R2*, PIM1, PLAG1, PLCG1*, PLCG2, PML, PMS1, PMS2, POLD1, POLE, POLR2A, POT1, PPARG*, PPM1D, PPP2R1A, PRDM1*, PREX2, PRKAR1A, PRKCI, PRKDC, PRPF40B, PRPF8, PRSS8, PTCH1, PTEN*, PTPN11, PTPRD, PTPRT, QKI, RAB35, RAC1*, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAF1*, RANBP2, RARA*, RASA1, RB1*, RBM10*, RECQL, RECQL4, REL, RELA, RET, RHOA, RICTOR*, RINT1, RIT1*, RNF43, ROS1*, RPS15, RPS20, RPTOR*, RRAGC, RSPO2, RSPO3, RUNX1, RUNX1T1, SAMD9, SAMD9L, SBDS, SDHA, SDHB, SDHC, SDHD, SETBP1, SETD2, SF1, SF3A1, SF3B1, SGK1, SH2B3, SLIT2, SLX4, SMAD2*, SMAD3, SMAD4*, SMARCA4, SMARCB1*, SMC1A, SMC3, SMO, SNCAIP, SOCS1, SOS1, SOX10, SOX2*, SOX9, SPEN, SPOP, SPTA1, SRC*, SRSF2, SS18, STAG2*, STAT3, STAT4, STAT5B, STAT6, STK11, SUFU, SUZ12, SYK, TAF1, TBL1XR1, TBX3, TCEB1 (ELOC), TCF12, TCF3, TCF7L2, TERC, TERT*, TET1, TET2, TFE3, TFEB, TGFBR2, TMPRSS2, TNFAIP3, TNFRSF14, TOP1*, TOP2A, TP53*, TP63*, TPMT, TRAF3, TRAF7, TSC1*, TSC2*, TSHR, TYK2, U2AF1, U2AF2, UBA1, USP6, VAV1, VEGFA, VHL, WHSC1 (NSD2), WISP3 (CCN6), WRN, WT1, XPC, XPO1, XRCC2, YAP1*, YWHAE, ZBTB2, ZMYM3*, ZNF217*

An asterisk (*) indicates that this gene is analyzed for copy number variations (CNVs).
Instructions:
Contact University of Iowa Diagnostic Laboratories
1-866-844-2522 (toll free)
319-384-7213 (Fax)