NPM1 Mutation Quantitative, MRD Monitoring and Interpretation
| Label Mnemonic: | NPM1BMQNT |
| Epic code: | LAB8829 |
| Order form: | Comprehensive Hematopathology Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 81310 |
Specimen(s):
Bone Marrow Aspirate
Collection Medium:
|
| Pink top tube 6 mL (K2-EDTA) |
Minimum:
5.0 mL Bone Marrow Aspirate in EDTA anti-coagulated pink top tube
Turn Around Time:
10-14 days upon receipt in laboratory
Comments:
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Methodology:
The NPM1 Mutation Quantitation assay uses multiplex reverse
transcription in combination with droplet digital PCR technology.
The type A NPM1 duplications occur in most AML cases. The assay can
reliably detect 1 tumor cell in a background of 20,000 normal cells.
The limit of quantitation is 0.005% NPM1/ABL1 ratio.
Instructions:
Testing requires dedicated collection tube.
Sample Processing:
Do Not Centrifuge.
Sample Storage:
Refrigerate.
Transport Instructions:
Place specimen into zip-lock type bag, seal bag.
Place packing list into outside pocket of bag.
Protect phlebotomy tube from excessive heat and ship in cooled container during summer months.
Recommend early AM overnight shipping or equivalent if not on courier service.
Ship refrigerated.
Place packing list into outside pocket of bag.
Protect phlebotomy tube from excessive heat and ship in cooled container during summer months.
Recommend early AM overnight shipping or equivalent if not on courier service.
Ship refrigerated.