NPM1 Mutation Quantitative, MRD Monitoring and Interpretation
| Label Mnemonic: | NPM1QNT |
| Epic code: | LAB8828 |
| Order form: | Comprehensive Hematopathology Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 81310 |
Specimen(s):
Whole Blood
Collection Medium:
 |
| Pink top tube 6 mL (K2-EDTA) |
Minimum:
5.0 mL Whole Blood in EDTA anti-coagulated pink top tube
Turn Around
Time:
10-14 days upon receipt in laboratory
Comments:
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Methodology:
The NPM1 Mutation Quantitation assay uses multiplex reverse
transcription in combination with droplet digital PCR technology. The
type A NPM1 duplications occur in most AML cases. The assay can
reliably detect 1 tumor cell in a background of 20,000 normal cells.
The limit of quantitation is 0.005% NPM1/ABL1 ratio.
Instructions:
Testing requires dedicated collection tube.
Sample
Processing:
Do Not Centrifuge.
Sample
Storage:
Refrigerate.
Transport
Instructions:
Place specimen into zip-lock type bag, seal bag.
Place requisition into outside pocket of bag.
Place packing list into outside pocket of bag.
Ship refrigerated.
Place requisition into outside pocket of bag.
Place packing list into outside pocket of bag.
Ship refrigerated.
CPT Code:
81310