Phospholipase A2 Receptor (PLA2R) Antibody, IgG with Reflex to Titer

Label Mnemonic:	PLA2R
Epic code:	LAB8739
Order form:	Laboratory Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	86255; if titer performed, 86256

Specimen(s):

Serum

Collection Medium:

Red top tube 5 mL (Clot Activator)

Minimum:

Preferred Minimum: 1.0 mL serum in red top tube
Absolute Minimum: 0.2 mL serum in red top tube

Rejection Criteria:

Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated.

Turn Around Time:

1-8 days upon receipt at reference laboratory

Reference Range:

Less than 1:10

Interpretive Data:

A positive result (1:10 or greater) for phospholipase A2 receptor antibody, IgG, in conjunction with other laboratory and clinical findings, supports a diagnosis of primary membranous glomerulonephritis (pMGN).

Comments:

This test aids in the differential diagnosis of membranous glomerulonephritis (MGN) or nephrotic syndrome of unknown etiology.

Note: If Phospholipase A2 Receptor Antibody, IgG is positive, then a Phospholipase Receptor A2 Antibody, IgG titer is reported. Additional charges apply.

Methodology:

Semi-Quantitative Indirect Fluorescent Antibody

Sample Processing:

Allow to clot completely at room temperature. Separate serum from cells ASAP.
Centrifuge within two hours of draw time.
Label transport tube with patient last name, first name, identification number, date and time of collection.
Transfer serum into new screw-capped plastic vial.

Sample Storage:

Store frozen.

Transport Instructions:

Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Place dry ice on top of specimen in Styrofoam container to maintain frozen temperature.

CPT Code:

86255; if titer performed, 86256