Liver-Kidney Microsome Antibody, IgG
| Label Mnemonic: | LKM |
| Epic code: | LAB8679 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 86376 |
Specimen(s):
Serum
Collection Medium:
|
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 0.5 mL serum
Absolute Minimum: 0.4 mL serum
Absolute Minimum: 0.4 mL serum
Turn Around Time:
1 day upon receipt at reference laboratory
Reference Range:
< or =20.0 Units (negative)
20.1-24.9 Units (equivocal)
> or =25.0 Units (positive)
Reference values apply to all ages.
20.1-24.9 Units (equivocal)
> or =25.0 Units (positive)
Reference values apply to all ages.
Interpretive Data:
Seropositivity for anti-LKM-1 antibodies is consistent with a
diagnosis of AIH type 2.
Comments:
Useful For:
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatitis
Cautions:
Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatitis
Cautions:
Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Sample Processing:
Centrifuge at 3500 RPM for 5 minutes.
Transfer serum into new labeled container and cap.
Relevant clinical information must be submitted with specimen in order to provide correct interpretation of test results.
Transfer serum into new labeled container and cap.
Relevant clinical information must be submitted with specimen in order to provide correct interpretation of test results.
Sample Storage:
Refrigerate serum 2-8°C.
Refrigerate.
Refrigerate.
Transport Instructions:
Place specimen into zip-lock type bag, seal bag.
Place requisition into outside pocket of bag.
Ship refrigerated.
Place requisition into outside pocket of bag.
Ship refrigerated.