Syphilis Treatment Follow-Up (RPR with Titer)
| Label Mnemonic: | STFP |
| Epic code: | LAB8648 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 86592 RPR; if reflexed, add 86593 RPR titer |
Specimen(s):
Serum
Collection Medium:
)
|
| BD Gold SST 5 mL Vacutainer |
Minimum:
5 mL serum from a BD Gold SST tube
Rejection Criteria:
CSF and other body fluids.
Turn Around Time:
1 day
Reference Range:
Non-reactive (< 1:1)
Comments:
If RPR is weakly reactive or reactive, then a titer to endpoint will
be added.
This test is intended for assessing treatment efficacy in patients who have been treated for syphilis. Successful treatment is generally indicated by a 4-fold reduction in RPR titer (e.g., 1:32 to 1:8).
Assay methodology changed to BioRad Bioplex method April 3, 2018.
For routine syphilis testing, "Syphilis Total Antibodies" should be ordered.
This test is intended for assessing treatment efficacy in patients who have been treated for syphilis. Successful treatment is generally indicated by a 4-fold reduction in RPR titer (e.g., 1:32 to 1:8).
Assay methodology changed to BioRad Bioplex method April 3, 2018.
For routine syphilis testing, "Syphilis Total Antibodies" should be ordered.
Test Limitations:
The assay is unaffected by icterus < 66 mg/dL, hemolysis (Hb <
500 mg/dL), or lipemia < 2000 mg/dL). RPR assay interference
resulting in false positive results may occur with cross-reacting
antibodies from patients diagnosed with systemic lupus
erythematosus, malaria, autoimmune disease, viral pneumonia, and
people who have been recently vaccinated (including vaccines for
SARS-CoV-2). RPR results should be interpreted in conjunction with
patient history, risk factors, and other syphilis testing.
Methodology:
Fluorescent Immunoassay
Sample Processing:
Centrifuge at a speed and time necessary to get barrier separation
of plasma/serum and cells within 1 hour of collection. Send specimen
in original tube. Do Not transfer to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample Storage:
Store frozen.
Transport Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal
bag.
Place completed requisition into outside pocket of bag.
Ship frozen.
Place completed requisition into outside pocket of bag.
Ship frozen.
See also:
Syphilis Total Antibodies with Reflex Confirmation, Serum
Syphilis Total Antibodies with Reflex Confirmation, Serum