Cancer Mutation Profiling Blood Paired Normal Testing
| Label Mnemonic: | CHPNML |
| Epic code: | LAB8080 |
| Order form: | Molecular Oncology Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 81445 |
Specimen(s):
Blood
Collection Medium:
|
| Pink top tube 6 mL (K2-EDTA) |
Minimum:
Collect blood in Pink top tube.
Testing Schedule:
Weekly
Turn Around Time:
21 days
Comments:
The Cancer Mutation Profiling test is a massively parallel next
generation DNA sequencing-based assay that targets commonly mutated
or hotspot regions of 50 cancer-related genes. Some testing requires
comparison to the patient's germline sequence and a peripheral blood
specimen will usually be sufficient.
Genes Assessed: ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, EGFR, ERBB2, ERBB4, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK2, JAK3, KDR, KIT, KRAS, MET, MLH1, MPL, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SMAD4, SMARC1, SMO, SRC, STK11, TP53, and VHL.
Genes Assessed: ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, EGFR, ERBB2, ERBB4, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK2, JAK3, KDR, KIT, KRAS, MET, MLH1, MPL, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SMAD4, SMARC1, SMO, SRC, STK11, TP53, and VHL.
Methodology:
Massively parallel Next Generation DNA sequencing by synthesis,
semiconductor technology, Ion Personal Genomics Machine
Sample Storage:
Refrigerate.
Transport Instructions:
Place specimen into zip-lock type bag, seal bag.
Recommend early AM overnight shipping or equivalent if not on courier service.
Ship refrigerated.
Place requisition into outside pocket of bag.
Recommend early AM overnight shipping or equivalent if not on courier service.
Ship refrigerated.
Place requisition into outside pocket of bag.