Sex Hormone Binding Globulin
Label Mnemonic: | SHBG |
Epic code: | LAB4945 |
Order form: | Laboratory Requisition |
Supply order: | Supply Order Form |
Billing: | Billing Policies |
CPT code: | 84270 |
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL whole blood in light green top or TWO
Microtainer® devices
Testing
Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
1 hour (upon receipt in laboratory)
Reference Range:
Males 10-80 nmol/L
Females, non-pregnant 20-130 nmol/L
Reference ranges are not well established during pregnancy, although pregnant women tend to have markedly higher SHBG plasma concentrations due to increased estrogen production. Reference ranges in pre- pubertal children tend to be higher than adults.
Females, non-pregnant 20-130 nmol/L
Reference ranges are not well established during pregnancy, although pregnant women tend to have markedly higher SHBG plasma concentrations due to increased estrogen production. Reference ranges in pre- pubertal children tend to be higher than adults.
Interpretive Data:
Elevated SHBG levels can be seen in elderly men, and are often found
in patients with hyperthyroidism and cirrhosis of the liver. SHBG
levels also increase when oral contraceptives or anti-epileptic drugs
are taken. Decreased SHBG concentrations are often seen with
hypothyroidism, polycystic ovarian syndrome, obesity, hirsutism,
elevated androgen levels, alopecia, and acromegaly.
Comments:
This assay may be significantly impacted by high-dose biotin (>5 mg
dose) taken within previous 12 hours. High concentrations of biotin
may lead to falsely decreased results. These concentrations may be
found in patients taking over-the-counter supplements with biotin
content much higher than nutritional requirements for biotin.
Specimens should not be collected until at least 12 hours after the
last dose.
Methodology:
Electrochemiluminescence Immunoassay
Sample
Processing:
Centrifuge at a speed and time necessary to get barrier separation of plasma/serum and cells within 1 hour of collection. Send specimen in original tube. Do Not transfer to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample
Storage:
Refrigerate.
Transport
Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
CPT Code:
84270
See Additional Information:
Biotin Interference with Immunoassays
Biotin Interference with Immunoassays