Synthetic Glucocorticoid Screen
| Label Mnemonic: | SGSU |
| Epic code: | LAB7665 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 82544 |
Specimen(s):
Urine
Collection Medium:
) |
| Urine (Random)-BD Vacutainer®, no additive yellow top |
Minimum:
5 mL random urine, no preservative
Turn Around
Time:
3-9 days upon receipt at reference laboratory
Reference Range:
Negative
Cutoff concentrations
Betamethasone: 0.10 mcg/dL
Budesonide: 0.20 mcg/dL
Dexamethasone: 0.10 mcg/dL
Fludrocortisone: 0.10 mcg/dL
Fluticasone propionate: 0.10 mcg/dL
Megestrol acetate: 0.10 mcg/dL
Methylprednisolone: 0.10 mcg/dL
Prednisolone: 0.10 mcg/dL
Prednisone: 0.10 mcg/dL
Triamcinolone acetonide: 0.10 mcg/dL
Cutoff concentrations
Betamethasone: 0.10 mcg/dL
Budesonide: 0.20 mcg/dL
Dexamethasone: 0.10 mcg/dL
Fludrocortisone: 0.10 mcg/dL
Fluticasone propionate: 0.10 mcg/dL
Megestrol acetate: 0.10 mcg/dL
Methylprednisolone: 0.10 mcg/dL
Prednisolone: 0.10 mcg/dL
Prednisone: 0.10 mcg/dL
Triamcinolone acetonide: 0.10 mcg/dL
Interpretive Data:
This test screens for and quantitates, if present, the following
synthetic glucocorticoids: beclomethasone dipropionate, betamethasone,
budesonide, dexamethasone, fludrocortisone, flunisolide,
fluorometholone, megestrol acetate, methylprednisolone, prednisolone,
prednisone, triamcinolone, and triamcinolone acetonide.
The presence of synthetic glucocorticoids in urine indicates current or recent use of these compounds. Since several of these compounds exceed the potency of endogenous cortisol by 1 or more orders of magnitude, even trace levels may be associated with Cushingoid features.
The presence of synthetic glucocorticoids in urine indicates current or recent use of these compounds. Since several of these compounds exceed the potency of endogenous cortisol by 1 or more orders of magnitude, even trace levels may be associated with Cushingoid features.
Comments:
Useful For:
Confirming the presence of the listed synthetic glucocorticoids (see Interpretive Data)
Confirming the cause of secondary adrenal insufficiency.
This assay does not detect fluticasone propionate.
Cautions:
This method cannot detect all of the available synthetic steroids either available as pharmaceutical compounds or chemicals present in food. The assay confirms only the listed synthetic glucocorticoids (see Interpretive Data).
Lack of detection does not preclude use of synthetic glucocorticoid because adrenal suppression may persist for some time after the exogenous steroid is discontinued.
Confirming the presence of the listed synthetic glucocorticoids (see Interpretive Data)
Confirming the cause of secondary adrenal insufficiency.
This assay does not detect fluticasone propionate.
Cautions:
This method cannot detect all of the available synthetic steroids either available as pharmaceutical compounds or chemicals present in food. The assay confirms only the listed synthetic glucocorticoids (see Interpretive Data).
Lack of detection does not preclude use of synthetic glucocorticoid because adrenal suppression may persist for some time after the exogenous steroid is discontinued.
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable
Isotope Dilution Analysis
Sample
Processing:
Label tube with two Full patient identifiers, date and time of collection.
Submit in leak-proof container.
Submit in leak-proof container.
Sample
Storage:
Store frozen.
Transport
Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed laboratory requisition (or packing list) into outside pocket of bag.
Place dry ice on top of specimen in Styrofoam container to maintain frozen temperature.
Ship frozen.
Place completed laboratory requisition (or packing list) into outside pocket of bag.
Place dry ice on top of specimen in Styrofoam container to maintain frozen temperature.
Ship frozen.
CPT Code:
82544
See Additional Information:
Urine Tests Requiring no Preservatives
Urine Tests Requiring no Preservatives