Anti-Müllerian Hormone
| Label Mnemonic: | AMH |
| Epic code: | LAB7364 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 83520 |
Specimen(s):
Blood
Collection Medium:
|
| Plasma Separator Tube 4.5 mL |
Minimum:
3 mL in light green top tube or TWO Microtainer® devices
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Sex / Age Reference Range Females / 20 up to 25 1.22-11.7 ng/mL Females / 25 up to 30 0.890-9.85 ng/mL Females / 30 up to 35 0.576-8.13 ng/mL Females / 35 up to 40 0.147-7.49 ng/mL Females / 40 up to 45 0.030-5.47 ng/mL
Interpretive Data:
Menopausal women or women with premature ovarian failure of any
cause (including after cancer chemotherapy) will generally have very
low antimüllerian hormone (AMH), often below the lower detection
limit of quantification (0.03 ng/mL). In women with polycystic
ovarian syndrome, AMH concentrations may be two- to five-fold higher
than age-appropriate reference intervals. Reference ranges for
females less than 20 years old have not been established for this
assay. AMH concentrations in women typically reach peak values
between 18-25 years old.
Reference ranges for males have not been established for this assay. However, AMH concentration in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended tests, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.
Test Limitations:
Cetrotide, Ovitrelle, Endometrin, and Follistatin may interfere with this AMH immunoassay. Do not measure AMH within 2 weeks of using these products.
The assay is unaffected by icterus (bilirubin is less than 66 mg/dL), hemolysis (Hb is less than 1,000 mg/dL), lipemia (Intralipid is less than 1000 mg/dL) and biotin is less than 1200 ng/mL. (criterion: recovery within plus or minus 10% of initial value).
Reference ranges for males have not been established for this assay. However, AMH concentration in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended tests, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.
Test Limitations:
Cetrotide, Ovitrelle, Endometrin, and Follistatin may interfere with this AMH immunoassay. Do not measure AMH within 2 weeks of using these products.
The assay is unaffected by icterus (bilirubin is less than 66 mg/dL), hemolysis (Hb is less than 1,000 mg/dL), lipemia (Intralipid is less than 1000 mg/dL) and biotin is less than 1200 ng/mL. (criterion: recovery within plus or minus 10% of initial value).
Comments:
Methodology:
Electrochemiluminescence Immunoassay (ECLIA)
Sample Processing:
Centrifuge at a speed and time necessary to get barrier separation
of plasma/serum and cells within 1 hour of collection. Send specimen
in original tube. Do Not transfer to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample Storage:
Refrigerate.
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
Transport Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal
bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
See Additional Information:
Biotin Interference with Immunoassays
Biotin Interference with Immunoassays