Non-HDL Cholesterol Calculation

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Beginning October 1, 2009, the "Lipid Panel" orderable within Epic will include a calculation for non-high density lipoprotein (non- HDL-C). Non-HDL-C is calculated as total cholesterol minus HDL. The addition of non-HDL-C to the Lipid Panel reflects the recognition of this calculated value as a predictive factor in cardiovascular disease based on the National Cholesterol Education III studies. The reference ranges for non-HDL-C are based on National Cholesterol Education III guidelines for adults 18 years and older:

 

Desirable: < 130 mg/dL
Borderline high: 139-159 mg/dL
High: 160-189 mg/dL
Very high: > or = 190 mg/dL

 

The Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents has set the following guidelines for lipids in a context of cardiovascular risk for children ages 2-17:

 

NON-HDL CHOLESTEROL

Acceptable: <120 mg/dL

Borderline High: 120-144 mg/dL

High: > or =145 mg/dL

 

Reference values have not been established for patients who are younger than 24 months.

 

Because non-HDL-C is simply a calculated parameter, there are no changes to the sample requirements for the "Lipid Panel".

 

References

  1. Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1-executive summary. J Clin Lipidol. 2014;8(5):473-488. doi: 10.1016/j.jacl.2014.07.007
  2. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report. Pediatrics. 2011 Dec;128 Suppl 5(Suppl 5):S213-S256. doi: 10.1542/peds.2009-2107C