C-erb-2 Oncoprotein

Label Mnemonic:	ICERB
Epic code:	LAB1915
Order form:	Anatomic Pathology Consult Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	88360 Cerb-2, 88360-26 Cerb-2 Professional Interpretation

Specimen(s):

Tissue

Collection Medium:

Tissue Block

Testing Schedule:

0800-1630 Monday through Friday.

Turn Around Time:

3 days

Reference Range:

The pathologist will provide an interpretative report.

Comments:

For further details, refer to Specimen Instructions.

C-erb-2 oncoprotein is the product of the HER-2 (neu) oncogene which 
is overexpressed in a variety of adenocarcinomas arising at various 
sites. Overexpression of c-erb-2 is present in 15-30% of cases of 
breast carcinoma and has been demonstrated to be a negative prognostic 
indicator.

C-erb-2 overexpression can be detected by immunohistochemical staining 
of formalin-fixed paraffin-embedded sections of tumor tissue. Membrane 
staining of the cells is the only reaction considered positive. A 
positive therapeutic response to Herceptin (TM) therapy with 
anti-C-erb-2 monoclonal antibody has been reported in association with 
3+ staining intensity.

Methodology:

Immunohistochemistry

Instructions:

Contact University of Iowa Diagnostic Laboratories
1-866-844-2522 (toll free)
319-384-7213 (Fax)