Levetiracetam (Keppra) Drug Level
| Label Mnemonic: | KEPPRA |
| Epic code: | LAB477 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 80177 |
Specimen(s):
Whole Blood
Collection Medium:
 |
| Pink top tube 6 mL (K2-EDTA) |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
5 mL pink top tube (adults) or ONE EDTA Microtainer®
devices (pediatric patients).
Rejection Criteria:
Gel separator tubes
Testing
Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around
Time:
1 hour (upon receipt in laboratory)
Reference Range:
Therapeutic range: 5-30 μg/mL
Comments:
The proposed therapeutic range for seizure control is 5-30 μg/mL.
Pharmacokinetics of levetiracetam are affected by renal function. The
relationship between serum concentrations and toxicity is not known.
Test
Limitations:
Hemolysis: No significant interference up to an H index of 1000
(approximate hemoglobin concentration: 1000 mg/dL).
Lipemia: No significant interference up to an L index of 1500 (approximate triglycerides concentration: 1500 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.
Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Lipemia: No significant interference up to an L index of 1500 (approximate triglycerides concentration: 1500 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.
Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Methodology:
Enzyme Immunoassay
Sample
Processing:
Centrifuge at a speed and time necessary to get barrier separation of plasma/serum and cells within 1 hour of collection.
Separate plasma into screw-capped plastic vial.
Do not send primary tube if all plasma has been transferred to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Separate plasma into screw-capped plastic vial.
Do not send primary tube if all plasma has been transferred to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample
Storage:
Refrigerate.
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
Transport
Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
CPT Code:
80177