Protein-Urine, Random

Label Mnemonic:	URPR
Epic code:	LAB845
Order form:	Laboratory Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	84156 (protein) 82570 (creatinine)

Specimen(s):

Urine, Random (Includes Prot/Creat Ratio)

Collection Medium:

Clear top tube

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3.0 mL random urine; no preservatives.

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

The reference range for the urine protein/creatinine ratio is < 0.2 for 2 years or older. Reference range for the ratio is not established for children less than 2 years old. No established reference range for random urine protein concentration.

Comments:

The urine protein/creatinine ratio is automatically calculated if 
a
urine protein and urine creatinine are ordered on the same specimen.  
The urine protein/creatinine ratio allows for an estimation of 
proteinuria based on a single random urine collection.  A 24 hour 
urine 
protein determination remains the recommended true measure of 
proteinuria.  The reference range for the urine protein/creatinine 
ratio is < 0.2 for 2 years or older.  Reference range for the ratio is 
not established for children less than 2 years old.

References:
   Morgenstern BZ, Butini L, Wollan P, et al. Am J Kid Dis 2003
   Apr;41(4):760-766

   National Kidney Foundation: Am J Kid Dis 2002;39:S93-S102 (suppl1)

   Wilson DM, Anderson RL.  Am J Clin Pathol 1993;100:419-424

Test Limitations:

Contamination of urine with menstrual blood, prostatic 
secretions, or semen may result in increased urine protein levels.  
Vigorous exercise in healthy individuals may result in increased urine 
protein levels.  Intra individual variability in creatinine clearance 
can be due to diet (e.g., amount of ingested meat) and total skeletal 
muscle mass.

Criterion: recovery plus or minus 10% of initial values

Icterus: No significant interference up to an I index of 45 
(approximate conjugated and unconjugated bilirubin concentration: 45 
mg/dL).

Hemolysis: No significant interference up to an H index of 50.

No significant interference from:
Ascorbic Acid    Creatinine       Glucose
Phosphorus       Urea             Magnesium
Sodium Citrate   Caffeine         Cefazolin Sodium
Chlorpromazine   Calcium          L-Dopa Gentamicin
Sulfate          Sodium Oxalate   Uric Acid

Methodology:

Turbidimetric (protein)
Kinetic Colorimetric (creatinine)

Sample Processing:

Submit in leak-proof container.

Sample Storage:

Refrigerate.

Transport Instructions:

Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.

CPT Code:

84156 (protein)
82570 (creatinine)

See Additional Information:
Urine Tests Requiring no Preservatives