Plasma Homocysteine

Beginning Monday, February 5, 2001, the Clinical Chemistry laboratory of the Department of Pathology will offer plasma homocysteine analysis. Plasma homocysteine is a recognized risk factor for cardiovascular disease.

Analytical Time: Performed Tuesday and Thursday afternoons; noon cutoff

Specimen Requirements:
Adults: 10 ml sodium heparin tube (green top)
Peds: Two 0.6 ml heparin microtainer (Lithium or sodium)

Collection Requirements: Fasting specimen preferred

Transportation Requirements: On ice, immediately after collection

NOTE: Phlebotomy team will collect specimens; however, patient care area will need to deliver on ice to Specimen Control, 6240 RCP.

Reference Range: 5.0 – 15.0 umol/L

Patient Charge: $92.25 (less than current charge for mailout test)

Questions can be directed to Ronald Feld at 6-1759.

1. Abby SL, et al. Homocysteine and cardiovascular disease. J Am Board Fam Pract 1998;11(5):391-8.

2. Brattstrom L, et al. Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 2000;72(2):315-23.

3. Gerhard GT, et al. Homocysteine and atherosclerosis. Curr Opin Lipdol 1999;10(5):417-28.

4. Nygard O. et al. Total homocysteine and cardiovascular disease. J Intern Med 1999;246(5):425-54.

5. Pasceri V, et al. Homocysteine and coronary heart disease: a review of the current evidence. Semin Interventional Cardiol 1999;4(3):121-8.

6. Refsum H, et al. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.

7. Scott CH, et al. Homocysteine: evidence for a causal relationship with cardiovascular disease. Cardiology in Review 1999;7(2):101-7.

8. Wu AH, et al. Multicenter analytical evaluation of an automated immunoassay for total plasma homocysteine. Ann Clin Lab Sci 2000;30(2):185-90.