Effective Tuesday, June 23, 2014, the detection of autoantibodies against phospholipase A2 receptor (PLA2R2) in human serum is now an orderable test in Epic (order code LAB8316).

This test is used as an aid in the diagnosis of primary membranous glomerulonephritis (pMGN), in conjunction with other laboratory and clinical findings.  pMGN is a chronic inflammatory disease of the renal glomeruli, which is accompanied by a progressive reduction in kidney function in the majority of patients.  Autoantibodies of class IgG against PLA2R are highly specific for the diagnosis of pMGN.  They can be detected in the serum of 52-82% of patients with pMGN.

Reference Range
Negative:	<14 units
Equivocal:	>14 – <20 units
Positive:	>20 units

Questions concerning testing can be directed to Danniele Holanda, MD (3-6212), or Lisa Horning MT(ASCP)SI (6-2688).