Anti-M├╝llerian Hormone Testing Now Available In Core Laboratory

Effective Tuesday, November 7, 2017, the University of Iowa Hospitals and Clinics core clinical chemistry laboratory will begin running the assay for Anti-Mullerian Hormone (AMH) (Epic # LAB7364). This assay will use the Roche Diagnostics Elecsys method. There is a significant shift in reference range compared to the mailout assay which used a different methodology. The new reference ranges are detailed below.

Details on the new assay are as follows:

• Specimen type: 4.5 mL light green plasma separator tube (PST)
• Minimum requirements (Adult): 3 mL whole blood from one light green plasma separator tube (PST)
• Minimum requirements (Peds): TWO light green top Microtainers┬« (pediatric patients)
• Test Availability: 24 hours/day, 7 days a week (including holidays)
• Turnaround Time: 1 hour upon receipt in laboratory

Reference range for females

20-24 years 1.22 - 11.7 ng/mL
25-29 years 0.890 - 9.85 ng/mL
30-34 years 0.576 - 8.13 ng/mL
35-39 years 0.147 - 7.49 ng/mL
40-44 years 0.030 - 5.47 ng/mL
Menopause or premature ovarian failure Near or below 0.03 ng/mL

In women with polycystic ovarian syndrome, AMH concentrations may be two- to five-fold higher than age-appropriate reference intervals. Reference ranges for females less than 20 years old have not been established for this assay. AMH concentrations in women typically reach peak values between 18-25 years old.

Reference ranges for males have not been established for this assay. However, AMH concentrations in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended testes, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.

Questions should be directed to Matthew Krasowski, MD, PhD, medical director of the Clinical Chemistry Laboratory (384-9380, matthew-krasowski@uiowa.edu).