Hepatitis B Core Antibody, IgG & IgM

Label Mnemonic:	HBCB
Epic code:	LAB622
Downtime form:	A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery

Chemistry
6240 RCP
356-3527

Specimen(s):

Plasma

Collection Medium:

Plasma Separator Tube 4.5 mL

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

5 mL whole blood from light green top tube or TWO light green top microtubes for pediatric patients

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

1 hour (upon receipt in laboratory)

Reference Range:

Negative

Interpretive Data:

A negative result indicates that anti-HBc antibodies were not detected in the sample. A positive result indicates presumptive evidence of hepatitis B virus infection. Anti-HBc antibodies were detected in the sample which suggests either on-going or previous HBV infection.

Comments:

Part of initial diagnostic hepatitis profile.

Current methods for the detection of anti-HBc antibodies may not detect all infected individuals. A negative test result does not exclude the possibility of exposure to or infection with HBV.

Assay updated with increased tolerance to biotin on 3/28/23.

Test Limitations:

The assay is unaffected by icterus < 25 mg/dL, hemolysis (Hb < 800 mg/dL), lipemia < 1000 mg/dL) and biotin is less than 1200 ng/mL..

Methodology:

Electrochemiluminescence Immunoassay

CPT Code:

86704

See Additional Information:
Biotin Interference with Immunoassays