Hepatitis A Antibody (G & M)
Label Mnemonic: HAVAB
Epic Lab Code: LAB620
Downtime Form: A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery
Chemistry
6240 RCP
356-3527
Specimen(s):
Plasma
Collection Medium:
Plasma Separator Tube 4.5 mL
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
3 mL whole blood from light green top tube or TWO Microtainer® devices for pediatric patients.
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
1 hour (upon receipt in laboratory)
Reference Range:
Negative
Interpretive Data:
The cutoff is set according to the WHO recommendation for vaccination. Results obtained with the Elecsys Anti-HAV assay are resulted as follows: Negative <18.0 IU/L Grayzone ≥18.0 <22.0 IU/L Positive ≥22.0 IU/L If clinically indicated, patients who have samples that are resulted as "Grayzone" should be re-tested in approximately two weeks.
Comments:
This assay may be significantly impacted by high-dose biotin (>5 mg dose) taken within previous 12 hours. High concentrations of biotin may lead to falsely decreased results. These concentrations may be found in patients taking over-the-counter supplements with biotin content much higher than nutritional requirements for biotin. Specimens should not be collected until at least 12 hours after the last dose.
Test Limitations:
The assay is unaffected by icterus (bilirubin < 855 μmol/L or < 50 mg/dL), hemolysis (< 1000 mg/dL), lipemia (Intralipid < 1500 mg/dL), and biotin < 205 nmol/L or < 50 ng/mL.

As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or have received them for diagnostic purposes. In rare cases, interference due to extremely high titers of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur. These effects are minimized by suitable test design.
Methodology:
Electrochemiluminescence Immunoassay
CPT Code:
86708
 
See Additional Information:
Biotin Interference with Immunoassays