|Downtime form:||A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery|
|Plasma Separator Tube 4.5 mL|
A1AT is an acute phase reactant, therefore any inflammatory process may result in transient elevations of the patient's A-1-AT level.
Criterion: Recovery within plus or minus 10% of initial values. Icterus: No significant interference up to an I index of 60 (approximate conjugated and unconjugated bilirubin concentration: 60 mg/dL). Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL). Lipemia (Intralipid): No significant interference up to an L index of 350 (approximate triglycerides concentration: 700 mg/dL). There is poor correlation between turbidity and triglycerides concentration. Rheumatoid factors less than 100 IU/mL do not interfere. No high dose hook effect is seen up to an alpha 1-antitrypsin concentration of 1200 mg/dL. Elevated estrogen levels (oral contraceptives; third trimester of pregnancy) give rise to false positive results. CRP and haptoglobin should therefore also be determined.* *Laurell CB, Kullander S, Thorell J. Effect of administration of a combined estrogen-progestin contraceptive on the level of individual plasma proteins. Scand J Lab Invest 1968;21:337-343.